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A Sample Module: Understanding the Role of the Gastric Mucosal Barrier as a Protective Mechanism (0 credit hours)
This sample module describes the features of the normal gastro-intestinal wall, so that students will understand the causes of disorders of the gastric mucosal barrier. These disorders include peptic ulcers and Type B chronic gastritis. The roles of prostaglandins, NSAIDS, alcohol, and H. pylori bacteria in gastric disorders are examined.
Denise Moore, MS, RT(R)
As a radiographer with over 35 years experience, most of Denise Moore’s professional life has focused on radiologic science education. Currently, she is professor in radiology and serves as the director of the Online Continuing Education Program for Sinclair Community College (Dayton, Ohio). Her teaching experience includes patient care, sectional anatomy, positioning, pathology, and principles of exposure. In addition, Ms. Moore is actively involved at the state and national professional levels. She is past-president and chair of the board of trustees for the Ohio Society of Radiologic Technologists and has served, in multiple capacities, as a member of its board of trustees since 1979. She currently serves as a member of the Board of Directors for the Joint Review Committee on Education in Radiologic Technology and has been appointed to many national- and state-level committees. In addition, she has presented at numerous conferences at the local, state and national levels.
Upon completion of this sample mini-module, learners will be able to:
  • Describe the general features of the normal GI wall.
  • Identify and describe the protective characteristics of the gastric mucosal barrier.
  • Recognize the role of prostaglandins as a consideration of the barrier.
  • Describe the effects of NSAIDS and alcohol on the barrier.
  • Describe the role of H. pylori in the development of peptic ulcer disease and Type B chronic gastritis.

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Guyton A.C., Hall J.E. Textbook of Medical Physiology. 9th ed. Philadelphia, PA: W.B. Saunders; 1996: 793-851.

Pezzi J.S., Shiau Y. Helicobacter pylori and gastrointestinal disease. American Family Physician. 1995; 52-6: 11717-1723.

Porth C. Alterations in gastrointestinal function. In: Porth, C, 5th ed. Pathophysiology: Concepts of Altered Health States. Philadelphia, PA: Lippincott; 1998: 719-744.

Wolfe M.M. NSAIDs and the gastrointestinal mucosal. Hospital Practice. 1996; 31-12: 37-47.


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