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Title

Radiation Biology, Part 3: Systemic Radiation Effects (1 credit hours)

Abstract

Systemic Radiation Effects is the third of eight in the Radiobiology and Radiation Protection program. It explores the biologic effects of whole-body irradiation. It closely follows the material in the previous modules and makes the transition from cellular to organ radiation damage. You will be introduced to the acute radiation syndrome, hematopoietic syndrome, gastrointestinal syndrome, and cerebrovascular syndrome. Although it is unlikely you personally will encounter these syndromes, knowledge of them is important for understanding other biologic effects.

Course Approval Expiration/End Date: August 1, 2011 Category A Credit

Author

Elsevier Inc.,

This module is adapted from Mosby's Radiography Online: Radiologic Physics, copyright © 2002 - 2004 by Elsevier (USA) reproduced by permission of Elsevier Inc. and edited for use as CE content by Denise Moore, Professor of Radiology, Sinclair Community College.

Objectives

Upon completion of this module, the learner should be able to:

Define the important terms in the module.
Identify the characteristics of radiation dose-response relationship and draw diagrams demonstrating the various radiation dose-response relationships.
Describe the causes and dose levels related to acute radiation syndrome.
List the stages of acute radiation syndrome.
List the predictable biologic effects of acute radiation syndrome: hematopoietic syndrome, gastrointestinal syndrome, and cerebrovascular syndrome.
Compare the radiation effects on an embryo-fetus to those on children and adults.
Identify the time periods of greatest radiosensitivity for an embryo-fetus.
Describe the concept of LD 50/30 and state the LD 50/30 for humans.
Define mean survival time.
Compare the effects of whole-body irradiation to the effects of radiation from diagnostic procedures.

Resources

Giffin N. Radiation Effects During Pregancy. 1996. Available at: http://trshare.triumf.ca/~safety/EHS/rpt/rpt_4/node30.html. Accessed July 1, 2009.

United Nations Scientific Committee on the Effects of Atomic Radiation (UNSCEAR). Appedix to Annex G, Early Effects in Man of High Radiation Doses: Acute Radiation Effects in Victims of the Chernobyl Accident. 1988. Available at: http://www.unscear.org/docs/reports/1988annexgappx.pdf. Accessed July 1, 2009.

Washington State Department of Health. Environmental Health Programs, Hanford Health Information Network. Genetic Effects and Birth Defects from Radiation Exposure. 1994-2004. Available at: http://www.doh.wa.gov/hanford/publications/overview/genetic.html. Accessed July 1, 2009.

WGBH Educational Foundation. Frontline. Nuclear Reaction: Why Do Americans Fear Nuclear Power? 1995-2006. Available at: http://www.pbs.org/wgbh/pages/frontline/shows/reaction/. Accessed July 1, 2009.

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